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KMID : 0388019950060010007
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Korean Journal Gynecologic Oncology and Colposcopy
1995 Volume.6 No. 1 p.7 ~ p.12
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Clinical Significance of p53 gene Expression with Immunohistochemical Staining in Ovarian Cancer
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김재욱
이연혜/김영태/이정필/김동규/송찬호
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Abstract
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Mutation of p53 gene is on of the commonest genetic changes in the development of human cancer including ovary. We investigated the diagnostic usefulness of the demonstration of p53 gene immunoreactivity in ovarian cancers, because
immunohistochemical
demonstration of p53 immunoreactivity is inexpensive, easily controlled and can be applied in routine pathology laboratories.
P53 immunoreactivity was not identified in any patients in whom there was no morphological evidence of neoplasia. In contrast, in 46% of patients of ovarian cancer, p53 immunoreactivity was identified.
Overexpression of p53 gene correlated with advanced stage but did not correlate with grade, cell type and tumor size.
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KEYWORD
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